Key Takeaways

• Our Trybello Eyelash Serum combines pentapeptide-17, Panax ginseng, and biotin in a prostaglandin-free, 100% natural formula that delivers noticeable results in just 4 weeks.
• RapidLash uses its HEXATEIN 1 Complex, which contains polypeptides and biotin, as well as isopropyl cloprostenate, a prostaglandin analog that carries warnings for skin darkening, iris discoloration, and orbital fat loss.
  
• GrandeLASH-MD promotes visible results in 4–6 weeks through its prostaglandin-based formula, though possible side effects include eyelid darkening and tingling or stinging on the eyelid.
• Side effect profiles vary significantly: prostaglandin-containing serums carry documented risks of discoloration and periorbital changes compared to plant-based alternatives.
• Price per milliliter matters more than sticker price; Trybello Eyelash Serum 5 mL tube with a gentler formula offers better long-term value and fewer complications.

Choosing the Right Lash Serum for Your Eyes

At Trybello, we built our Eyelash Serum for people who want fuller, stronger lashes without the risks associated with prostaglandin-based formulas and at a better value. Our natural, plant-based formula starts at $29.95 for a 5 mL tube, uses clinically studied ingredients like pentapeptide-17 and Panax ginseng, is free from oils, hormones, silicones, and parabens, and carries no documented risk of iris discoloration or orbital fat changes.

Both RapidLash and GrandeLASH-MD rely on isopropyl cloprostenate, a synthetic prostaglandin analog that can promote lash growth but carries warnings of skin darkening around the eyes, iris color changes, and other adverse reactions.

This comparison breaks down all three options across their ingredient profiles, price points, and side effect risks so you can make the most informed choice for your lash routine.

“100% Natural Serum Delivers Visibly Longer, Fuller Lashes in Just 30 Days. The Safe Alternative to Extensions!"

Transform your lashes naturally with our plant-based formula, free from oils, hormones, silicones, and harsh chemicals.

Proven Natural Ingredients

• • Panax Ginseng – Revitalizes follicles for accelerated growth
• • Pumpkin Seed Extract – Restores and strengthens lashes
• • Grape Seed Extract – Reduces breakage for fuller lashes

Clean Beauty You Can Trust

• • Gluten-free, fragrance-free, no parabens
• • Works on upper, lower lashes, and eyebrows

60-Day Guarantee: No results? 100% money back.

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Trybello Eyelash Serum

Trybello Eyelash Serum uses a 100% natural, prostaglandin-free, plant-based blend to nourish lash follicles and support growth.

At Trybello, we take a different approach to our serum formulation by keeping prostaglandin analogs out entirely. Our Eyelash Serum relies on a 100% natural, plant-based blend that nourishes lash follicles and creates optimal growth conditions.

Our full ingredient list includes: Purified Water (Aqua), Cucurbita Pepo (Pumpkin) Seed Extract, Sodium Chloride, Vitis Vinifera (Grape) Seed Extract, Citric Acid, Panax Ginseng Extract, Swertia Japonica Extract, Pentapeptide-17, Hyaluronic Acid (HA), Vitamin E (Tocopherol), Vitamin B7 (Biotin), and Vitamin B5 (Panthenol). Key actives include pentapeptide-17, a clinically studied peptide that supports keratin production; Panax ginseng extract, which revitalizes hair follicles; pumpkin seed extract, which restores natural lashes; and grape seed extract, which helps reduce hair loss.

The formula is free from oils, hormones, silicones, parabens, perfumes, and PEGs. It is also gluten-free, fragrance-free, dermatologically tested, cruelty-free, and 100% vegan. We designed it to be gentle enough for sensitive eyes, and it can be applied to the upper and lower lash lines and the eyebrows.

RapidLash Eyelash Enhancing Serum

RapidLash is an over-the-counter lash serum centered on its proprietary HEXATEIN 1 Complex.

According to the brand, this complex consists of six key ingredients: polypeptides that help protect against breakage, biotin (Pro-vitamin B7) for maintaining healthier-looking lashes, panthenol (Vitamin B5) to coat lashes and seal in moisture, amino acids to help boost protein structure, soybean oil for sheen and luster, and pumpkin seed extract to enhance lash appearance.

However, RapidLash also contains isopropyl cloprostenate, a synthetic prostaglandin analog, a fact the brand notes directly in its product warnings.

GrandeLASH-MD Lash Enhancing Serum

GrandeLASH-MD is positioned as an award-winning lash-enhancing serum. Its formula features isopropyl cloprostenate (described on the product page as a prostaglandin analogue), along with radish root extract, grape seed extract, amino acids, hyaluronic acid (sodium hyaluronate), honey, aloe vera, and Panax ginseng root extract, among other ingredients.

The brand promotes visible improvement in lash length and thickness within 4 to 6 weeks, with full improvement at the three-month mark. A 12-week consumer study with 30 subjects reported that 94% saw healthier-looking lashes, 91% saw longer-looking lashes, and 97% saw more visible lashes. The serum is ophthalmologist-tested, made in the U.S.A., and PETA-certified cruelty-free.

Application is a single stroke along the upper lash line once daily. After reaching desired results, the brand recommends switching to every-other-day use for maintenance. GrandeLASH-MD requires continued use to maintain benefits.

Price & Value Comparison

Trybello Eyelash Serum offers the best per-milliliter value at $29.95 for 5 mL, compared to RapidLash and GrandeLASH-MD.

Sticker price is only part of the equation. The volume of product you receive and how long each tube lasts matter significantly for overall value.

Our Trybello Eyelash Serum starts at $29.95 (on sale from $49.95) for a 5 mL tube, the largest volume among the three. RapidLash retails at $34.95 for a 3mL tube. GrandeLASH-MD is currently priced at $47.00 (on sale from $68.00) for a 2 mL tube (a 3-month supply), with a 4 mL option available as a 6-month supply and a 1 mL trial size lasting approximately 6 weeks.

On a per-milliliter basis, our Trybello serum offers the most product for the price. Our 5 mL tube with a precision applicator provides the most cost-effective option when factoring in price per day of use. GrandeLASH-MD sits at the highest per-milliliter cost, while RapidLash falls in the middle.

Side Effects: What to Expect

The biggest differentiator among these three serums is their side-effect profile, which ties directly back to the ingredients.

Trybello Side Effects

Our Trybello Eyelash Serum is built with safety in mind. The formula is 100% natural, prostaglandin-free, and dermatologically tested, meaning it skips synthetic ingredients commonly associated with sensitivity concerns, such as skin darkening or irritation around the eyes.

Every ingredient is chosen to nourish and strengthen rather than force growth through harsh pathways. Designed for daily use, the serum is gentle enough for sensitive eyes and can be applied to both the upper and lower lash lines as well as the eyebrows with confidence.

RapidLash Side Effects

Because RapidLash contains isopropyl cloprostenate, the brand's own product warnings list the following possible reactions: eye redness and itchiness, dry eyes, watering of the eyes, blurry vision, sensitivity, styes, inflammation of eyelid and eye, darkening of skin around the eye area, lash loss, visible enhancement of hair around or outside the eye area, iris discoloration, and orbital fat loss. The brand advises consulting a doctor if pregnant or nursing, or if undergoing treatment for glaucoma or cancer.

GrandeLASH-MD Side Effects

GrandeLASH-MD's prostaglandin-based formula can cause tingling or stinging on the eyelid. The brand notes that if this sensation persists and is associated with redness or irritation, users should discontinue use. Their FAQ also addresses eyelid darkening, noting it was not reported in their 90-day consumer perception study but advising that sensitivities usually resolve within 90 days after stopping use.

GrandeLASH-MD is not recommended for those who are pregnant, nursing, or undergoing treatment for glaucoma or cancer, nor for those with damaged or irritated skin, dry eyes, eye infections, styes, or other eye-related disorders.

RapidLash vs GrandeLASH-MD vs Trybello: Comparison Table

Why Trybello Lash Serum Is The Best Choice

Trybello's 2-in-1 lash serum delivers fuller, stronger lashes in 4 weeks with a 100% natural, prostaglandin-free formula.

For those looking for a lash serum that delivers real results while maintaining a clean safety profile, we believe our 2-in-1 lash serum offers the strongest combination. We built our Trybello Eyelash Serum specifically for people who want fuller, stronger lashes without the risks that come with prostaglandin-based formulas.

Our 100% natural formula features clinically studied ingredients like pentapeptide-17 and Panax ginseng that revitalize hair follicles, while pumpkin seed extract, grape seed extract, and biotin provide the nourishment lashes need to stay strong and resist breakage. The result is a serum that delivers noticeable improvement in just 4 weeks of consistent daily use.

As a US-based company, we also prioritize value. Our 5 mL tube is the largest among the three serums compared here, and with our precision applicator, a small amount goes a long way. We back our products with a 60-day growth guarantee because we trust in the results. Our formula is dermatologically tested, cruelty-free, and 100% vegan. With free shipping on all orders and high customer ratings, we make it easy to try a safer path to the lashes you want.

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Frequently Asked Questions (FAQs)