Key Takeaways

• Our Trybello Eyelash Serum uses a plant-based, prostaglandin-free formula with pentapeptide-17, panax ginseng, and biotin.
• RapidLash uses its HEXATEIN 1 Complex, which contains biotin, peptides, and panthenol, as well as isopropyl cloprostenate, a prostaglandin analog.
  
• RevitaLash Advanced features its BioPeptin Complex alongside DDDE, a prostaglandin analog that has established potential side effects.
• Side-effect risks vary significantly: prostaglandin-based serums may cause iris darkening and periorbital fat loss, while our prostaglandin-free formula poses far fewer concerns.
• With a 60-day growth guarantee and prices starting at $29.95, Trybello Eyelash Serum delivers dermatologically tested lash care at the best price point compared to prostaglandin-based alternatives.

Choosing the Right Lash Serum for Healthier, Fuller Lashes

Not all lash serums are created equal, and the differences between them can directly affect your eye health. Our Trybello Eyelash Serum is built primarily on a plant-based, prostaglandin-free formula of pentapeptide-17, panax ginseng, and biotin that delivers visible results in as little as four weeks.

By contrast, RapidLash and RevitaLash both rely on prostaglandin analogs to stimulate lash growth, and both carry documented risks, including iris color changes, periorbital fat loss, and chronic dry eye. This comparison breaks down the ingredients, expected timelines, and side effects of all three serums so you can make an informed choice for your daily routine.

“100% Natural Serum Delivers Visibly Longer, Fuller Lashes in Just 30 Days. The Safe Alternative to Extensions!"

Transform your lashes naturally with our plant-based formula, free from oils, hormones, silicones, and harsh chemicals.

Proven Natural Ingredients

• • Panax Ginseng – Revitalizes follicles for accelerated growth
• • Pumpkin Seed Extract – Restores and strengthens lashes
• • Grape Seed Extract – Reduces breakage for fuller lashes

Clean Beauty You Can Trust

• • Gluten-free, fragrance-free, no parabens
• • Works on upper, lower lashes, and eyebrows

60-Day Guarantee: No results? 100% money back.

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Trybello Eyelash Serum

Trybello's plant-based eyelash serum uses pentapeptide-17 and botanical extracts to support natural lash growth without prostaglandin analogs.

Trybello Eyelash Serum relies on a plant-based blend of active ingredients, including pentapeptide-17, panax ginseng extract, pumpkin seed extract, grape seed extract, hyaluronic acid, biotin (vitamin B7), panthenol (vitamin B5), and vitamin E. Carnauba wax and candelilla cera provide emollient conditioning, while swertia japonica extract and citric acid round out the formula.

Pentapeptide-17 is particularly notable here. This peptide signals lash follicles to produce more keratin, supporting natural growth without manipulating hormone-like pathways. Panax ginseng revitalizes follicles and supports microcirculation, while grape seed extract delivers antioxidant protection and pumpkin seed extract supplies zinc and essential fatty acids to nourish the lash root.

Our formula is free from hormones, parabens, silicones, PEGs, perfumes, and oils. It is also vegan, cruelty-free, gluten-free, fragrance-free, and dermatologically tested. Our serum starts at $29.95, making it the most affordable of the three options and the gentlest. As a US-based company, we back our product with a 60-day growth guarantee, offering a full refund if you don't see results after consistent application.

RapidLash Eyelash Enhancing Serum

RapidLash is built around its proprietary HEXATEIN 1 Complex, a blend of six active ingredients: (Image source: Amazon)

RapidLash Eyelash Enhancing Serum is a blend of six active ingredients: polypeptides, biotin, panthenol, amino acids, soybean oil, and pumpkin seed extract. Together, these ingredients are designed to hydrate, condition, and strengthen lashes while reducing breakage.

The full ingredient list also includes sodium hyaluronate for moisture retention, copper tripeptide-1 for follicle support, and allantoin for soothing the lash line. However, the formula also contains isopropyl cloprostenate, a synthetic prostaglandin analog.

This ingredient class was originally developed for glaucoma treatment, and while it is effective at promoting lash growth, it carries documented risks, including ocular irritation, iris color changes, and eyelid inflammation.

RevitaLash Advanced Eyelash Conditioner

RevitaLash Advanced was developed by ophthalmologist Michael Brinkenhoff, M.D., and is marketed as a physician-formulated lash conditioner. (Image source: RevitaLash)

RevitaLash Advanced's core technology is the proprietary BioPeptin Complex, which combines peptides, biotin, lipids, and green tea extract rich in panthenol. The formula also includes botanical extracts such as calendula, panax ginseng, saw palmetto, swertia japonica, and wheat germ protein.

The ingredient that sets RevitaLash apart from gentler competitors is dechloro dihydroxy difluoro ethylcloprostenolamide (DDDE), a synthetic prostaglandin analog. This compound is chemically related to bimatoprost, the active ingredient in the prescription treatment Latisse. DDDE is what gives RevitaLash its strong growth-promoting effects, but it is also what causes the most side effects.

RevitaLash Advanced is one of the more expensive options in the lash serum market. The 2.0 mL size (3-month supply) retails at $100, while the 3.5 mL size (6-month supply) costs $152. The application is once daily, and the brand cites an independent consumer study showing improvements in nourishment, length, and fullness among participants. The product labeling also carries a caution noting that it contains a prostaglandin analog and is not recommended for use if pregnant, nursing, or undergoing treatment for glaucoma or cancer.

Side Effects: Prostaglandin-Free vs. Prostaglandin Serums

The most important distinction between these three serums lies in their active growth mechanisms and the side effects associated with each.

Trybello prostaglandin-free formula sidesteps the most serious concerns entirely. Because our serum relies on peptides, botanical extracts, and vitamins rather than hormone-mimicking compounds, it carries a much lower risk of adverse reactions. This makes it a particularly suitable option for people with sensitive eyes.

RapidLash and RevitaLash, by contrast, both contain prostaglandin analogs (isopropyl cloprostenate and DDDE, respectively). These compounds extend the growth phase of the lash cycle, producing noticeable length and density gains. However, they also carry potential risks that users should weigh carefully.

Reported side effects across prostaglandin-based lash serums include temporary redness, itching, and burning around the eyes; darkening of the eyelid skin along the lash line; iris color changes (particularly in lighter-colored eyes); periorbital fat loss (sunken appearance around the eyes); and dry eyes and meibomian gland dysfunction.

RevitaLash's product labeling acknowledges that a small percentage of users have reported reactions, including temporary redness, swelling, itching, a burning sensation in the eyes, dry eyes, watering of the eyes, styes, temporary darkening of the skin at the lash line, periorbital fat loss, and eyelash loss.

Results & Timelines

Trybello users report visible lash improvements by week four, while RapidLash and RevitaLash typically require six to eight weeks.

At Trybello, our users commonly report feeling stronger, healthier lashes within the first two weeks, with visible length and density improvements by week four. Full results typically develop by week eight, with continued improvements over longer use. Our 60-day growth guarantee provides a safety net for users who want to try the product risk-free.

RapidLash generally requires six to eight weeks of nightly use before most users see noticeable improvements in length and fullness. The brand's own consumer study of 102 subjects over 56 days supports an eight-week timeline, though some users report improved lash condition within the first two weeks.

RevitaLash cites eight weeks as the benchmark for significant results based on its independent consumer study. Some users experience faster improvements, but the brand recommends patience and consistent application for optimal outcomes.

RapidLash vs RevitaLash vs Trybello: Comparison Table

Why Trybello Lash Serum Stands Out

Trybello's prostaglandin-free 2-in-1 eyelash serum offers plant-based lash growth starting at $29.95 with a 60-day guarantee.

At Trybello, we created our 2-in-1 Eyelash serum for a simple reason: you shouldn't have to risk your eye health to get the lashes you want. It is built primarily on a plant-based, prostaglandin-free formula that prioritizes both effectiveness and safety. Every ingredient, from pentapeptide-17 to panax ginseng to grape seed extract, was selected for its proven ability to nourish lash follicles and support natural growth without harsh chemicals.

We know that trust matters. That's why we back our serum with a 60-day growth guarantee. If you don't see results after consistent, documented daily use, you'll get your money back. Additionally, our formula is dermatologically tested, vegan, and cruelty-free.

The serum is also free from hormones, parabens, silicones, PEGs, perfumes, and oils, making it gentle enough for sensitive eyes and safe for contact lens wearers. With prices starting at $29.95, we deliver premium lash care at the best price point.

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Frequently Asked Questions (FAQs)